Ontology highlight
ABSTRACT:
SUBMITTER: Shikora JM
PROVIDER: S-EPMC7003886 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Chemical science 20190819 40
Saturated heterocycles are important components of many bioactive compounds. The method disclosed herein enables a general route to a range of 5-, 6- and 7-membered oxygen and nitrogen heterocycles by coupling potassium alkyltrifluoroborates with heteroatom-tethered alkenes, predominantly styrenes, under copper-catalyzed conditions, in the presence of MnO<sub>2</sub>. The method was applied to the synthesis of the core of the anti-depressant drug citalopram. The reaction scope and observed react ...[more]