Ontology highlight
ABSTRACT:
SUBMITTER: Cui H
PROVIDER: S-EPMC7003928 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Cui Haiyang H Cao Hao H Cai Haiying H Jaeger Karl-Erich KE Davari Mehdi D MD Schwaneberg Ulrich U
Chemistry (Weinheim an der Bergstrasse, Germany) 20191203 3
A main remaining challenge in protein engineering is how to recombine beneficial substitutions. Systematic recombination studies show that poorly performing variants are usually obtained after recombination of 3 to 4 beneficial substitutions. This limits researchers in exploiting nature's potential in generating better enzymes. The Computer-assisted Recombination (CompassR) strategy provides a selection guide for beneficial substitutions that can be recombined to gradually improve enzyme perform ...[more]