Ontology highlight
ABSTRACT:
SUBMITTER: Stein-Thoeringer CK
PROVIDER: S-EPMC7003985 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Stein-Thoeringer C K CK Nichols K B KB Lazrak A A Docampo M D MD Slingerland A E AE Slingerland J B JB Clurman A G AG Armijo G G Gomes A L C ALC Shono Y Y Staffas A A Burgos da Silva M M Devlin S M SM Markey K A KA Bajic D D Pinedo R R Tsakmaklis A A Littmann E R ER Pastore A A Taur Y Y Monette S S Arcila M E ME Pickard A J AJ Maloy M M Wright R J RJ Amoretti L A LA Fontana E E Pham D D Jamal M A MA Weber D D Sung A D AD Hashimoto D D Scheid C C Xavier J B JB Messina J A JA Romero K K Lew M M Bush A A Bohannon L L Hayasaka K K Hasegawa Y Y Vehreschild M J G T MJGT Cross J R JR Ponce D M DM Perales M A MA Giralt S A SA Jenq R R RR Teshima T T Holler E E Chao N J NJ Pamer E G EG Peled J U JU van den Brink M R M MRM
Science (New York, N.Y.) 20191101 6469
Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and mortality. We found that <i>Enterococcus</i> also expands in the mouse gastrointestinal tract after allo-HCT a ...[more]