Ontology highlight
ABSTRACT:
SUBMITTER: Lenz C
PROVIDER: S-EPMC7004109 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lenz Claudius C Wick Jonas J Braga Daniel D García-Altares María M Lackner Gerald G Hertweck Christian C Gressler Markus M Hoffmeister Dirk D
Angewandte Chemie (International ed. in English) 20191204 4
Upon injury, psychotropic psilocybin-producing mushrooms instantly develop an intense blue color, the chemical basis and mode of formation of which has remained elusive. We report two enzymes from Psilocybe cubensis that carry out a two-step cascade to prepare psilocybin for oxidative oligomerization that leads to blue products. The phosphatase PsiP removes the 4-O-phosphate group to yield psilocin, while PsiL oxidizes its 4-hydroxy group. The PsiL reaction was monitored by in situ <sup>13</sup> ...[more]