Ontology highlight
ABSTRACT:
SUBMITTER: Potjewyd F
PROVIDER: S-EPMC7004250 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Potjewyd Frances F Turner Anne-Marie W AW Beri Joshua J Rectenwald Justin M JM Norris-Drouin Jacqueline L JL Cholensky Stephanie H SH Margolis David M DM Pearce Kenneth H KH Herring Laura E LE James Lindsey I LI
Cell chemical biology 20191209 1
Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small-molecule inhibitors while moving beyond the restrictions of traditional pharmacology. Here, we report a chemical degrader (UNC6852) that targets polycomb repressive complex 2 (PRC2). UNC6852 contains an EED226-derived ligand and a ligand for VHL which bind to the WD4 ...[more]