Ontology highlight
ABSTRACT:
SUBMITTER: Ehrens A
PROVIDER: S-EPMC7004383 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Ehrens Alexandra A Lunde Christopher S CS Jacobs Robert T RT Struever Dominique D Koschel Marianne M Frohberger Stefan J SJ Lenz Franziska F Fendler Martina M Turner Joseph D JD Ward Stephen A SA Taylor Mark J MJ Freund Yvonne R YR Stefanakis Rianna R Easom Eric E Li Xianfeng X Plattner Jacob J JJ Hoerauf Achim A Hübner Marc P MP
PLoS neglected tropical diseases 20200127 1
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that targets endosymbiotic Wolbachia bacteria from filarial nematodes and compared its efficacy to doxycycline and rifampicin. Doxycycline and rifampicin were previously shown to deplete Wolbachia endosymbionts leading to a permanent sterilization of the fe ...[more]