Ontology highlight
ABSTRACT:
SUBMITTER: Hubner MP
PROVIDER: S-EPMC7365463 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Hübner Marc P MP Martin Coralie C Specht Sabine S Koschel Marianne M Dubben Bettina B Frohberger Stefan J SJ Ehrens Alexandra A Fendler Martina M Struever Dominique D Mitre Edward E Vallarino-Lhermitte Nathaly N Gokool Suzanne S Lustigman Sara S Schneider Manfred M Townson Simon S Hoerauf Achim A Scandale Ivan I
PLoS neglected tropical diseases 20200706 7
A major impediment to eliminate lymphatic filariasis and onchocerciasis is the lack of effective short-course macrofilaricidal drugs or regimens that are proven to be safe for both infections. In this study we tested oxfendazole, an anthelmintic shown to be well tolerated in phase 1 clinical trials. In vitro, oxfendazole exhibited modest to marginal motility inhibition of adult worms of Onchocerca gutturosa, pre-adult worms of Onchocerca volvulus and Onchocerca lienalis microfilariae. In vivo, f ...[more]