Ontology highlight
ABSTRACT:
SUBMITTER: Quan Q
PROVIDER: S-EPMC7004545 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Quan Qianghua Q Wang Xudong X Lu Chunyang C Ma Wenzong W Wang Yugang Y Xia Guoliang G Wang Chao C Yang Gen G
Cancer science 20200117 2
Collective invasion of cancer cells is the key process of circulating tumor cell (CTC) cluster formation, and greatly contributes to metastasis. Cancer stem-like cells (CSC) have a distinct advantage of motility for metastatic dissemination. To verify the role of CSC in the collective invasion, we performed 3D assays to investigate the collective invasion from cancer cell spheroids. The results demonstrated that CSC can significantly promote both collective and single-cell invasion. Further stud ...[more]