Ontology highlight
ABSTRACT:
SUBMITTER: Lo UG
PROVIDER: S-EPMC6420704 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lo U-Ging UG Bao Jiming J Cen Junjie J Yeh Hsin-Chih HC Luo Junhang J Tan Wanlong W Hsieh Jer-Tsong JT
American journal of clinical and experimental urology 20190218 1
Interferon is known as a pleiotropic factor in innate immunity, cancer immunity and therapy. Despite an objective short-term response of interferon (IFN) therapy in renal cell carcinoma (RCC) patients, the potential adverse effect of IFN on RCC cells is not fully understood. In this study, we demonstrate that IFNs can enhance RCC invasion via a new mechanism of IFIT5-mediated tumor suppressor microRNA (miRNA) degradation resulted in the elevation of Slug and ZEB1 and epithelial-to-mesenchymal tr ...[more]