Ontology highlight
ABSTRACT:
SUBMITTER: Hajicek N
PROVIDER: S-EPMC7004563 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Hajicek Nicole N Keith Nicholas C NC Siraliev-Perez Edhriz E Temple Brenda Rs BR Huang Weigang W Zhang Qisheng Q Harden T Kendall TK Sondek John J
eLife 20191231
Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological processes, including chemotaxis, platelet aggregation, and adaptive immunity. In turn, aberrant activation of PLC-γ1 and PLC-γ2 is implicated in inflammation, autoimmunity, and cancer. Although structures of isolated domains from PLC-γ isozymes are available, these structures are insufficient to define how release of basal autoinhibition is coupl ...[more]