Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
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ABSTRACT:
SUBMITTER: Konishi S
PROVIDER: S-EPMC7004802 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
Konishi Shizuka S Tanaka Natsuki N Mashimo Tomoji T Yamamoto Takashi T Sakuma Tetsushi T Kaneko Takehito T Tanaka Miyuu M Izawa Takeshi T Yamate Jyoji J Kuwamura Mitsuru M
Experimental animals 20190723 1
Spontaneous hhy mice show hydrocephalus and subcortical heterotopia, and a mutation in the Ccdc85c gene has been identified. To contribute to the comparison of the role of Ccdc85c in different species, we established a Ccdc85c KO rat and investigated its pathological phenotypes. Ccdc85c KO rats were produced by genomic engineering using transcription activator-like effector nuclease (TALEN). The KO rats had an approximately 350-bp deletion in Ccdc85c and lacked CCDC85C protein expression. The KO ...[more]
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