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TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus.

ABSTRACT: Hydrocephalus is a serious condition that impacts patients of all ages. The standards of care are surgical options to divert, or inhibit production of, cerebrospinal fluid; to date, there are no effective pharmaceutical treatments, to our knowledge. The causes vary widely, but one commonality of this condition is aberrations in salt and fluid balance. We have used a genetic model of hydrocephalus to show that ventriculomegaly can be alleviated by inhibition of the transient receptor potential vanilloid 4, a channel that is activated by changes in osmotic balance, temperature, pressure and inflammatory mediators. The TRPV4 antagonists do not appear to have adverse effects on the overall health of the WT or hydrocephalic animals.

SUBMITTER: Hochstetler AE

PROVIDER: S-EPMC7526552 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus.

Hochstetler Alexandra E AE Smith Hillary M HM Preston Daniel C DC Reed Makenna M MM Territo Paul R PR Shim Joon W JW Fulkerson Daniel D Blazer-Yost Bonnie L BL

JCI insight 20200917 18

Hydrocephalus is a serious condition that impacts patients of all ages. The standards of care are surgical options to divert, or inhibit production of, cerebrospinal fluid; to date, there are no effective pharmaceutical treatments, to our knowledge. The causes vary widely, but one commonality of this condition is aberrations in salt and fluid balance. We have used a genetic model of hydrocephalus to show that ventriculomegaly can be alleviated by inhibition of the transient receptor potential va ...[more]

PMID: 32938829

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