"Designer cytokines" targeting the tumor vasculature-think global and act local.
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ABSTRACT:
SUBMITTER: Kammertoens T
PROVIDER: S-EPMC7005528 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
"Designer cytokines" targeting the tumor vasculature-think global and act local.
Kammertoens Thomas T Kemna Josephine J Leisegang Matthias M
EMBO molecular medicine 20200109 2
Tumor necrosis factor (TNF) was discovered in 1975 as a lipopolysaccharide-induced serum factor that causes necrosis of tumors (Carswell et al, 1975). It was later found that TNF and cachectin, a factor causing wasting disease, were one and the same molecule (Beutler et al, 1985). Studies on the inflammatory activity of TNF have been translated into clinical success, namely blocking antibodies used to suppress autoimmune diseases. Research on TNF anti-tumor activity, in contrast, has not yet res ...[more]
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