Ontology highlight
ABSTRACT:
SUBMITTER: Dragan M
PROVIDER: S-EPMC7005685 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell death & disease 20200207 2
Triple-negative breast cancer (TNBC) is a highly metastatic and deadly disease. TNBC tumors lack estrogen receptor (ERα), progesterone receptor (PR), and HER2 (ErbB2) and exhibit increased glutamine metabolism, a requirement for tumor growth. The G protein-coupled kisspeptin receptor (KISS1R) is highly expressed in patient TNBC tumors and promotes malignant transformation of breast epithelial cells. This study found that TNBC patients displayed elevated plasma kisspeptin levels compared with hea ...[more]