Proline-promoted dehydroxylation of ?-ketols.
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ABSTRACT:
SUBMITTER: Mostinski Y
PROVIDER: S-EPMC7006627 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Proline-promoted dehydroxylation of α-ketols.
Mostinski Yelena Y Lankri David D Konovalov Yana Y Nataf Riva R Tsvelikhovsky Dmitry D
Chemical science 20190819 40
A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups. ...[more]
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