Ontology highlight
ABSTRACT:
SUBMITTER: Griffiths RL
PROVIDER: S-EPMC7006965 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Griffiths Rian L RL Konijnenberg Albert A Viner Rosa R Cooper Helen J HJ
Analytical chemistry 20190513 11
Native liquid extraction surface analysis (LESA) mass spectrometry allows direct analysis of folded proteins and protein complexes from biological substrates, such as dried blood spots and thin tissue sections, by use of native-like extraction/ionization solvents. Previously, we have demonstrated native LESA mass spectrometry of folded proteins up to 16 kDa as well as the 64 kDa hemoglobin tetramer, from mouse tissues. With denaturing LESA solvents, the highest mass protein detected in tissue to ...[more]