Ontology highlight
ABSTRACT:
SUBMITTER: Pfeifer GP
PROVIDER: S-EPMC7007358 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Journal of molecular biology 20190808 6
5-Methylcytosine (5mC), the major modified DNA base in mammalian cells, can be oxidized enzymatically to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the Ten-Eleven-Translocation (TET) family of proteins. Whereas 5fC and 5caC are recognized and removed by base excision repair proteins, the 5hmC base accumulates to substantial levels in certain cell types such as brain-derived neurons and is viewed as a relatively stable DNA base. As such, the existence ...[more]