Ontology highlight
ABSTRACT:
SUBMITTER: Ninova M
PROVIDER: S-EPMC7007863 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Ninova Maria M Chen Yung-Chia Ariel YA Godneeva Baira B Rogers Alicia K AK Luo Yicheng Y Fejes Tóth Katalin K Aravin Alexei A AA
Molecular cell 20191231 3
Regulation of transcription is the main mechanism responsible for precise control of gene expression. Whereas the majority of transcriptional regulation is mediated by DNA-binding transcription factors that bind to regulatory gene regions, an elegant alternative strategy employs small RNA guides, Piwi-interacting RNAs (piRNAs) to identify targets of transcriptional repression. Here, we show that in Drosophila the small ubiquitin-like protein SUMO and the SUMO E3 ligase Su(var)2-10 are required f ...[more]