Ontology highlight
ABSTRACT:
SUBMITTER: Deng G
PROVIDER: S-EPMC7008219 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Deng G G Song X X Greene M I MI
Clinical and experimental immunology 20190903 3
Regulatory T cells (T<sub>regs</sub> ) are specialized in immune suppression and play a dominant role in peripheral immune tolerance. T<sub>reg</sub> cell lineage development and function maintenance is determined by the forkhead box protein 3 (FoxP3) transcriptional factor, whose activity is fine-tuned by its post-translational modifications (PTMs) and interaction partners. In this review, we summarize current studies in the crystal structures, the PTMs and interaction partners of FoxP3 protei ...[more]