Dataset Information

Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.

ABSTRACT: The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of dioxins (PCDD/Fs) and DL-PCBs in feed and food. The data from experimental animal and epidemiological studies were reviewed and it was decided to base the human risk assessment on effects observed in humans and to use animal data as supportive evidence. The critical effect was on semen quality, following pre- and postnatal exposure. The critical study showed a NOAEL of 7.0 pg WHO2005-TEQ/g fat in blood sampled at age 9 years based on PCDD/F-TEQs. No association was observed when including DL-PCB-TEQs. Using toxicokinetic modelling and taking into account the exposure from breastfeeding and a twofold higher intake during childhood, it was estimated that daily exposure in adolescents and adults should be below 0.25 pg TEQ/kg bw/day. The CONTAM Panel established a TWI of 2 pg TEQ/kg bw/week. With occurrence and consumption data from European countries, the mean and P95 intake of total TEQ by Adolescents, Adults, Elderly and Very Elderly varied between, respectively, 2.1 to 10.5, and 5.3 to 30.4 pg TEQ/kg bw/week, implying a considerable exceedance of the TWI. Toddlers and Other Children showed a higher exposure than older age groups, but this was accounted for when deriving the TWI. Exposure to PCDD/F-TEQ only was on average 2.4- and 2.7-fold lower for mean and P95 exposure than for total TEQ. PCDD/Fs and DL-PCBs are transferred to milk and eggs, and accumulate in fatty tissues and liver. Transfer rates and bioconcentration factors were identified for various species. The CONTAM Panel was not able to identify reference values in most farm and companion animals with the exception of NOAELs for mink, chicken and some fish species. The estimated exposure from feed for these species does not imply a risk.

SUBMITTER: EFSA Panel on Contaminants in the Food Chain (CONTAM)

PROVIDER: S-EPMC7009407 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.

Knutsen Helle Katrine HK Alexander Jan J Barregård Lars L Bignami Margherita M Brüschweiler Beat B Ceccatelli Sandra S Cottrill Bruce B Dinovi Michael M Edler Lutz L Grasl-Kraupp Bettina B Hogstrand Christer C Nebbia Carlo Stefano CS Oswald Isabelle P IP Petersen Annette A Rose Martin M Roudot Alain-Claude AC Schwerdtle Tanja T Vleminckx Christiane C Vollmer Günter G Wallace Heather H Fürst Peter P Håkansson Helen H Halldorsson Thorhallur T Lundebye Anne-Katrine AK Pohjanvirta Raimo R Rylander Lars L Smith Andrew A van Loveren Henk H Waalkens-Berendsen Ine I Zeilmaker Marco M Binaglia Marco M Gómez Ruiz José Ángel JÁ Horváth Zsuzsanna Z Christoph Eugen E Ciccolallo Laura L Ramos Bordajandi Luisa L Steinkellner Hans H Hoogenboom Laurentius Ron LR

EFSA journal. European Food Safety Authority 20181120 11

The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of dioxins (PCDD/Fs) and DL-PCBs in feed and food. The data from experimental animal and epidemiological studies were reviewed and it was decided to base the human risk assessment on effects observed in humans and to use animal data as supportive evidence. The critical effect was on semen quality, following pre- and postnatal exposure. The critical study showed a NOAEL of ...[more]

PMID: 32625737

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Project description:Moniliformin (MON) is a mycotoxin with low molecular weight primarily produced by Fusarium fungi and occurring predominantly in cereal grains. Following a request of the European Commission, the CONTAM Panel assessed the risk of MON to human and animal health related to its presence in food and feed. The limited information available on toxicity and on toxicokinetics in experimental and farm animals indicated haematotoxicity and cardiotoxicity as major adverse health effects of MON. MON causes chromosome aberrations in vitro but no in vivo genotoxicity data and no carcinogenicity data were identified. Due to the limitations in the available toxicity data, human acute or chronic health-based guidance values (HBGV) could not be established. The margin of exposure (MOE) between the no-observed-adverse-effect level (NOAEL) of 6.0 mg/kg body weight (bw) for cardiotoxicity from a subacute study in rats and the acute upper bound (UB) dietary exposure estimates ranged between 4,000 and 73,000. The MOE between the lowest benchmark dose lower confidence limit (for a 5% response - BMDL05) of 0.20 mg MON/kg bw per day for haematological hazards from a 28-day study in pigs and the chronic dietary human exposure estimates ranged between 370 and 5,000,000 for chronic dietary exposures. These MOEs indicate a low risk for human health but were associated with high uncertainty. The toxicity data available for poultry, pigs, and mink indicated a low or even negligible risk for these animals from exposure to MON in feed at the estimated exposure levels under current feeding practices. Assuming similar or lower sensitivity as for pigs, the CONTAM Panel considered a low or even negligible risk for the other animal species for which no toxicity data suitable for hazard characterisation were identified. Additional toxicity studies are needed and depending on their outcome, the collection of more occurrence data on MON in food and feed is recommended to enable a comprehensive human risk assessment.

Dataset Information

Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.

Publications

Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.

Similar Datasets

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