Dataset Information

Refined exposure assessment of extracts of rosemary (E 392) from its use as food additive.

ABSTRACT: The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion on the refined exposure assessment of extracts of rosemary (E 392) when used as a food additive. Extracts of rosemary (E 392) was evaluated by the AFC Panel in 2008. Following this EFSA evaluation, extracts of rosemary (E 392) was authorised for use as a food additive in the EU in several food categories with maximum levels. In 2015, the ANS Panel provided a scientific opinion on the safety of the proposed extensions of use for extracts of rosemary (E 392) in fat-based spreads. In 2016, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) has evaluated this food additive and established a temporary acceptable daily intake (ADI) of 0-0.3 mg/kg body weight (bw) for rosemary extract, expressed as carnosic acid plus carnosol. Based on the data provided by food industry, the Panel was able to refine the exposure estimates of extracts of rosemary (E 392). The highest mean refined exposure estimate (non-brand loyal scenario) was 0.09 mg/kg bw per day in children (3-9 years) and the highest 95th percentile of exposure was 0.20 mg/kg bw per day in children. Taking uncertainties into account, the Panel concluded that these exposure estimates very likely overestimate the real exposure to extracts of rosemary (E 392) from its use as a food additive according to Annex II. Margins of safety were estimated for children and adults using the refined exposure estimate; these are higher than the ones calculated in 2015. Intake of carnosic acid and carnosol from natural diet (herbs) was estimated. It was maximally 1.66 mg/kg bw per day (p95).

SUBMITTER: EFSA Panel on Food Additives and Nutrient Sources added to Food (EFSA ANS Panel)

PROVIDER: S-EPMC7009710 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Refined exposure assessment of extracts of rosemary (E 392) from its use as food additive.

Younes Maged M Aggett Peter P Aguilar Fernando F Crebelli Riccardo R Dusemund Birgit B Filipič Metka M Frutos Maria Jose MJ Galtier Pierre P Gott David D Gundert-Remy Ursula U Kuhnle Gunter Georg GG Lambré Claude C Lillegaard Inger Therese IT Moldeus Peter P Mortensen Alicja A Oskarsson Agneta A Stankovic Ivan I Waalkens-Berendsen Ine I Woutersen Rudolf Antonius RA Wright Matthew M Boon Polly P Lindtner Oliver O Tlustos Christina C Tard Alexandra A Leblanc Jean-Charles JC

EFSA journal. European Food Safety Authority 20180802 8

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion on the refined exposure assessment of extracts of rosemary (E 392) when used as a food additive. Extracts of rosemary (E 392) was evaluated by the AFC Panel in 2008. Following this EFSA evaluation, extracts of rosemary (E 392) was authorised for use as a food additive in the EU in several food categories with maximum levels. In 2015, the ANS Panel provided a scientific opinion on the safety of ...[more]

PMID: 32626018

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Dataset Information

Refined exposure assessment of extracts of rosemary (E 392) from its use as food additive.

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Refined exposure assessment of extracts of rosemary (E 392) from its use as food additive.

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