Ontology highlight
ABSTRACT:
SUBMITTER: Wlodarczyk MT
PROVIDER: S-EPMC7009786 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wlodarczyk Marek T MT Dragulska Sylwia A SA Camacho-Vanegas Olga O Dottino Peter R PR Jarzęcki Andrzej A AA Martignetti John A JA Mieszawska Aneta J AJ
ACS biomaterials science & engineering 20180109 2
Platinum therapy represents first line of treatment in many malignancies but its high systemic toxicity limits the therapeutic dosage. Herein, we report the synthesis of carboplatin-like complexes with azide and alkyne functional groups and the formation of a platinum (II) - nuclear localization sequence peptide (Pt-NLS) hybrid to improve the import of platinum (II) complexes directly into the cell's nucleus. The Pt-NLS hybrid successfully enters cells and their nuclei, forming Pt-induced nuclea ...[more]