Ontology highlight
ABSTRACT:
SUBMITTER: Chen C
PROVIDER: S-EPMC7010232 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chen Chun C Jiang ZhiYing Z Fu Xin X Yu Diankun D Huang Hai H Tasker Jeffrey G JG
Cell reports 20191201 13
In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons. Here, we reveal a form of neuronal-astrocytic signaling that transmits retrograde dendritic signals to distal upstream neurons in order to activate recurrent synaptic circuits. Norepinephrine activates α<sub>1</sub> adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic rel ...[more]