Ontology highlight
ABSTRACT:
SUBMITTER: McEvoy E
PROVIDER: S-EPMC7708487 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
McEvoy Eoin E Han Yu Long YL Guo Ming M Shenoy Vivek B VB
Nature communications 20201201 1
Sustained proliferation is a significant driver of cancer progression. Cell-cycle advancement is coupled with cell size, but it remains unclear how multiple cells interact to control their volume in 3D clusters. In this study, we propose a mechano-osmotic model to investigate the evolution of volume dynamics within multicellular systems. Volume control depends on an interplay between multiple cellular constituents, including gap junctions, mechanosensitive ion channels, energy-consuming ion pump ...[more]