Ontology highlight
ABSTRACT:
SUBMITTER: Groisman AI
PROVIDER: S-EPMC7011182 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Groisman Ayelén I AI Yang Sung M SM Schinder Alejandro F AF
Cell reports 20200101 1
A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibitory networks remains unknown. We used optogenetics to study synaptogenesis between new GCs and GABAergic interneurons expressing parvalbumin (PV-INs) and somatostatin (SST-INs). PV-INs target the soma, and synapses become mature after 6 weeks. This transitio ...[more]