Ontology highlight
ABSTRACT:
SUBMITTER: Temprana SG
PROVIDER: S-EPMC4329739 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Temprana Silvio G SG Mongiat Lucas A LA Yang Sung M SM Trinchero Mariela F MF Alvarez Diego D DD Kropff Emilio E Giacomini Damiana D Beltramone Natalia N Lanuza Guillermo M GM Schinder Alejandro F AF
Neuron 20141218 1
Developing granule cells (GCs) of the adult dentate gyrus undergo a critical period of enhanced activity and synaptic plasticity before becoming mature. The impact of developing GCs on the activity of preexisting dentate circuits remains unknown. Here we combine optogenetics, acute slice electrophysiology, and in vivo chemogenetics to activate GCs at different stages of maturation to study the recruitment of local target networks. We show that immature (4-week-old) GCs can efficiently drive dist ...[more]