Ontology highlight
ABSTRACT:
SUBMITTER: Kruger AN
PROVIDER: S-EPMC7012382 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Kruger Alyssa N AN Brogley Michele A MA Huizinga Jamie L JL Kidd Jeffrey M JM de Rooij Dirk G DG Hu Yueh-Chiang YC Mueller Jacob L JL
Current biology : CB 20191017 21
The mammalian sex chromosomes harbor an abundance of newly acquired ampliconic genes, although their functions require elucidation [1-9]. Here, we demonstrate that the X-linked Slx and Slxl1 ampliconic gene families represent mouse-specific neofunctionalized copies of a meiotic synaptonemal complex protein, Sycp3. In contrast to the meiotic role of Sycp3, CRISPR-loxP-mediated multi-megabase deletions of the Slx (5 Mb) and Slxl1 (2.3Mb) ampliconic regions result in post-meiotic defects, abnormal ...[more]