Ontology highlight
ABSTRACT:
SUBMITTER: Shi L
PROVIDER: S-EPMC6614581 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Shi Lin L Zhou Ting T Huang Qian Q Zhang Shiyang S Li Wei W Zhang Ling L Hess Rex A RA Pazour Gregory J GJ Zhang Zhibing Z
Biology of reproduction 20190701 1
Intraflagellar transport protein 74 (IFT74) is a component of the core intraflagellar transport complex, a bidirectional movement of large particles along the axoneme microtubules for cilia formation. In this study, we investigated its role in sperm flagella formation and discovered that mice deficiency in Ift74 gene in male germ cells were infertile with low sperm count and immotile sperm. The few developed spermatozoa displayed misshaped heads and short tails. Transmission electron microscopy ...[more]