Ontology highlight
ABSTRACT:
SUBMITTER: Philpott JM
PROVIDER: S-EPMC7012598 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Philpott Jonathan M JM Narasimamurthy Rajesh R Ricci Clarisse G CG Freeberg Alfred M AM Hunt Sabrina R SR Yee Lauren E LE Pelofsky Rebecca S RS Tripathi Sarvind S Virshup David M DM Partch Carrie L CL
eLife 20200211
Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of CK1 in eukaryotes, little is known about its regulation and the factors that influence substrate selectivity on functionally antagonistic sites in PERIOD that directly control circadian period. Here we describe a molecular switch involving a highly conserved anion binding site in CK1. This switch controls conformat ...[more]