Dataset Information

Driven by Pain, Not Gain: Computational Approaches to Aversion-Related Decision Making in Psychiatry.

ABSTRACT: Although it is well known that "losses loom larger than gains," computational approaches to aversion-related decision making (ARDM) for psychiatric disorders is an underdeveloped area. Computational models of ARDM have been implemented primarily as state-dependent reinforcement learning models with bias parameters to quantify Pavlovian associations, and differential learning rates to quantify instrumental updating have been shown to depend on context, involve complex cost calculations, and include the consideration of counterfactual outcomes. Little is known about how individual differences influence these models relevant to anxiety-related conditions or addiction-related dysfunction. It is argued that model parameters reflecting 1) Pavlovian biases in the context of reinforcement learning or 2) hyperprecise prior beliefs in the context of active inference play an important role in the emergence of dysfunctional avoidance behaviors. The neural implementation of ARDM includes brain areas that are important for valuation (ventromedial prefrontal cortex) and positive reinforcement-related prediction errors (ventral striatum), but also aversive processing (insular cortex and cerebellum). Computational models of ARDM will help to establish a quantitative explanatory account of the development of anxiety disorders and addiction, but such models also face several challenges, including limited evidence for stability of individual differences, relatively low reliability of tasks, and disorder heterogeneity. Thus, it will be necessary to develop robust, reliable, and model-based experimental probes; recruit larger sample sizes; and use single case experimental designs for better pragmatic and explanatory biological models of psychiatric disorders.

SUBMITTER: Paulus MP

PROVIDER: S-EPMC7012695 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Driven by Pain, Not Gain: Computational Approaches to Aversion-Related Decision Making in Psychiatry.

Paulus Martin P MP

Biological psychiatry 20190909 4

Although it is well known that "losses loom larger than gains," computational approaches to aversion-related decision making (ARDM) for psychiatric disorders is an underdeveloped area. Computational models of ARDM have been implemented primarily as state-dependent reinforcement learning models with bias parameters to quantify Pavlovian associations, and differential learning rates to quantify instrumental updating have been shown to depend on context, involve complex cost calculations, and inclu ...[more]

PMID: 31653478

Similar Datasets

Project description:BackgroundScientists striving to unlock mysteries within complex biological systems face myriad barriers in effectively integrating available information to enhance their understanding. While experimental techniques and available data sources are rapidly evolving, useful information is dispersed across a variety of sources, and sources of the same information often do not use the same format or nomenclature. To harness these expanding resources, scientists need tools that bridge nomenclature differences and allow them to integrate, organize, and evaluate the quality of information without extensive computation.ResultsSidekick, a genomic data driven analysis and decision making framework, is a web-based tool that provides a user-friendly intuitive solution to the problem of information inaccessibility. Sidekick enables scientists without training in computation and data management to pursue answers to research questions like "What are the mechanisms for disease X" or "Does the set of genes associated with disease X also influence other diseases." Sidekick enables the process of combining heterogeneous data, finding and maintaining the most up-to-date data, evaluating data sources, quantifying confidence in results based on evidence, and managing the multi-step research tasks needed to answer these questions. We demonstrate Sidekick's effectiveness by showing how to accomplish a complex published analysis in a fraction of the original time with no computational effort using Sidekick.ConclusionsSidekick is an easy-to-use web-based tool that organizes and facilitates complex genomic research, allowing scientists to explore genomic relationships and formulate hypotheses without computational effort. Possible analysis steps include gene list discovery, gene-pair list discovery, various enrichments for both types of lists, and convenient list manipulation. Further, Sidekick's ability to characterize pairs of genes offers new ways to approach genomic analysis that traditional single gene lists do not, particularly in areas such as interaction discovery.

Dataset Information

Driven by Pain, Not Gain: Computational Approaches to Aversion-Related Decision Making in Psychiatry.

Publications

Driven by Pain, Not Gain: Computational Approaches to Aversion-Related Decision Making in Psychiatry.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets