Ontology highlight
ABSTRACT:
SUBMITTER: Lu W
PROVIDER: S-EPMC7013065 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lu Wei W Fu Dongliang D Kong Xiangxing X Huang Zhiheng Z Hwang Maxwell M Zhu Yingshuang Y Chen Liubo L Jiang Kai K Li Xinlin X Wu Yihua Y Li Jun J Yuan Ying Y Ding Kefeng K
Cancer medicine 20200101 4
Early identification of metastatic or recurrent colorectal cancer (CRC) patients who will be sensitive to FOLFOX (5-FU, leucovorin and oxaliplatin) therapy is very important. We performed microarray meta-analysis to identify differentially expressed genes (DEGs) between FOLFOX responders and nonresponders in metastatic or recurrent CRC patients, and found that the expression levels of WASHC4, HELZ, ERN1, RPS6KB1, and APPBP2 were downregulated, while the expression levels of IRF7, EML3, LYPLA2, D ...[more]