Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira-Ferrer L
PROVIDER: S-EPMC7013901 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Oliveira-Ferrer Leticia L Milde-Langosch Karin K Eylmann Kathrin K Rossberg Maila M Müller Volkmar V Schmalfeldt Barbara B Witzel Isabell I Wellbrock Jasmin J Fiedler Walter W
International journal of molecular sciences 20200117 2
During the last few years, diverse studies have shown that tumors can actively interact with the lymphatic system and promote metastases development. In order to examine the molecular mechanisms involved in this interaction, we co-cultured tumor and lymphatic endothelial cells (LEC) and subsequently analyzed the molecular alterations of LECs. Therefore, LECs were co-cultivated with either a highly or weakly metastatic breast cancer cell line using contact (mixture) and non-contact (transwell) co ...[more]