Ontology highlight
ABSTRACT:
SUBMITTER: Sato Y
PROVIDER: S-EPMC7014430 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Sato Yuji Y Okuyama Torayuki T
International journal of molecular sciences 20200108 2
Although the advent of enzyme replacement therapy (ERT) for mucopolysaccharidoses (MPS) has paved the way for the treatment for these hereditary disorders, the blood brain barrier (BBB) has prevented patients with MPS involving the central nervous system (CNS) from benefitting from ERT. Therefore, finding ways to increase drug delivery into the brain across the BBB remains a crucial challenge for researchers and clinicians in the field. Attempts have been made to boost brain uptake of enzymes by ...[more]