Ontology highlight
ABSTRACT:
SUBMITTER: Nechemia-Arbely Y
PROVIDER: S-EPMC7015266 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature cell biology 20190603 6
Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites are identified within the megabase-long, repetitive α-satellite DNAs at each centromere. CENP-A is shown in early G1 to be assembled into nucleosomes within each centromere and onto 11,390 transcriptionally active sites on the chromosome arms. DNA replication is demonstrated to re ...[more]