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Hypnotics with novel modes of action.


ABSTRACT: Insomnia and, more generally, lack of sleep are on the rise. Traditionally treated by classical hypnotics, such as benzodiazepines and Z drugs, which both act on the GABAA receptor, and other modalities, including nondrug therapies, such as cognitive behavioural therapy, there is a range of new hypnotics which are being developed or have recently received market approval. Suvorexant and the like target the orexin/hypocretin system: they should have less side effects in terms of drug-drug interactions with e.g. alcohol, less memory impairment and dependence potential compared to classical hypnotics.

SUBMITTER: Hoyer D 

PROVIDER: S-EPMC7015741 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Hypnotics with novel modes of action.

Hoyer Daniel D   Allen Andrew A   Jacobson Laura H LH  

British journal of clinical pharmacology 20200117 2


Insomnia and, more generally, lack of sleep are on the rise. Traditionally treated by classical hypnotics, such as benzodiazepines and Z drugs, which both act on the GABA<sub>A</sub> receptor, and other modalities, including nondrug therapies, such as cognitive behavioural therapy, there is a range of new hypnotics which are being developed or have recently received market approval. Suvorexant and the like target the orexin/hypocretin system: they should have less side effects in terms of drug-d  ...[more]

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