Ontology highlight
ABSTRACT:
SUBMITTER: Ryu Y
PROVIDER: S-EPMC7016263 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
iScience 20200131 2
Mechanical forces are known to be involved in various biological processes. However, it remains unclear whether brain functions are mechanically regulated under physiological conditions. Here, we demonstrate that treadmill running and passive head motion (PHM), both of which produce mechanical impact on the head, have similar effects on the hallucinogenic 5-hydroxytryptamine (5-HT) receptor subtype 2A (5-HT<sub>2A</sub>) signaling in the prefrontal cortex (PFC) of rodents. PHM generates intersti ...[more]