Ontology highlight
ABSTRACT:
SUBMITTER: Bishop DC
PROVIDER: S-EPMC7016334 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Bishop David C DC Caproni Lisa L Gowrishankar Kavitha K Legiewicz Michal M Karbowniczek Kinga K Tite John J Gottlieb David J DJ Micklethwaite Kenneth P KP
Molecular therapy. Methods & clinical development 20200116
CD19-specific chimeric antigen receptor (CAR19) T cells, generated using viral vectors, are an efficacious but costly treatment for B cell malignancies. The nonviral <i>piggyBac</i> transposon system provides a simple and inexpensive alternative for CAR19 T cell production. Until now, <i>piggyBac</i> has been plasmid based, facilitating economical vector amplification in bacteria. However, amplified plasmids have several undesirable qualities for clinical translation, including bacterial genetic ...[more]