Ontology highlight
ABSTRACT:
SUBMITTER: Dubourg V
PROVIDER: S-EPMC7017252 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Dubourg Virginie V Nolze Alexander A Kopf Michael M Gekle Michael M Schwerdt Gerald G
Cells 20200107 1
Environmental food contaminants constitute a threat to human health. For instance, the globally spread mycotoxin Ochratoxin A (OTA) contributes to chronic kidney damage by affecting proximal tubule cells via unknown mechanisms. We applied a top-down approach to identify relevant toxicological mechanisms of OTA using RNA-sequencing followed by in-depth bioinformatics analysis and experimental validation. Differential expression analyses revealed that OTA led to the regulation of gene expression i ...[more]