Ontology highlight
ABSTRACT:
SUBMITTER: Nanda N
PROVIDER: S-EPMC7017295 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Genes 20200117 1
Next-generation sequencing has led to the recent discovery of several novel pancreatic cancer susceptibility genes. These genes include ataxia telangiectasia mutated (<i>ATM</i>), a serine/threonine kinase that is an integral component of DNA repair. Pathogenic germline <i>ATM</i> variants are frequently identified in patients with pancreatic ductal adenocarcinoma (PDAC) with and without a family history of the disease. Loss of <i>ATM</i> is also a frequent somatic event in the development of PD ...[more]