Ontology highlight
ABSTRACT:
SUBMITTER: Hutchings D
PROVIDER: S-EPMC7403604 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20190708 12
Germline pathogenic variants in the ATM serine/threonine kinase (ATM) gene are associated with an increased risk of pancreatic ductal adenocarcinoma. It is important to identify germline ATM pathogenic variants in pancreatic cancer patients because these alterations are potentially targetable with chemotherapeutic drugs and/or radiation and have implications for other family members. As germline pathogenic variants in other genes have been associated with distinct histologic subtypes of pancreat ...[more]