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Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children.


ABSTRACT: BACKGROUND:The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship with ADS. The objective of this study was to assess the levels of Hg in hair in a group of ASD children (chronic exposure) and in urinary excretion (acute exposure), in comparison to a healthy group. METHODS:A case-control study was conducted in Spanish children. We compared 54 ASD children (aged 2-6) with no other associated pathology to a normally-developing control group (54 subjects). RESULTS:There were no differences in urine (p:0.631) and hair (p:1.000) samples percentages below the limits of detection between the control and the ASD groups, and also between patients in the regression ASD subgroup (AMR) (p:0.08) and the non-regression ASD subgroup (ANMR) (p:0.705). When the analysis was adjusted for age and sex, the differences between Hg levels maintained not significant. There were no correlations between Hg concentrations in the ASD group as a whole (p: 0.739), or when they were subdivided into ASD-AMR (p: 0.739) and ASD-ANMR (p: 0.363). CONCLUSIONS:The present study shows no evidence in our geographical area to support an association between mercury neurotoxicity and the etiopathogenesis of ASD.

SUBMITTER: Gil-Hernandez F 

PROVIDER: S-EPMC7017444 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children.

Gil-Hernández Fernando F   Gómez-Fernández Antonio R AR   la Torre-Aguilar María Josede MJ   Pérez-Navero Juan L JL   Flores-Rojas Katherine K   Martín-Borreguero Pilar P   Gil-Campos Mercedes M  

Italian journal of pediatrics 20200212 1


<h4>Background</h4>The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship with ADS. The objective of this study was to assess the levels of Hg in hair in a group of ASD children (chronic exposure) and in urinary excretion (acute exposure), in comparison to a healthy group.<h4>Methods</h4>A case-control study was conducted in Spanish children. We  ...[more]

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