Ontology highlight
ABSTRACT:
SUBMITTER: Iwaki H
PROVIDER: S-EPMC7017876 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Iwaki Hirotaka H Blauwendraat Cornelis C Leonard Hampton L HL Kim Jonggeol J JJ Liu Ganqiang G Maple-Grødem Jodi J Corvol Jean-Christophe JC Pihlstrøm Lasse L van Nimwegen Marlies M Hutten Samantha J SJ Nguyen Khanh-Dung H KH Rick Jacqueline J Eberly Shirley S Faghri Faraz F Auinger Peggy P Scott Kirsten M KM Wijeyekoon Ruwani R Van Deerlin Vivianna M VM Hernandez Dena G DG Gibbs J Raphael JR Chitrala Kumaraswamy Naidu KN Day-Williams Aaron G AG Brice Alexis A Alves Guido G Noyce Alastair J AJ Tysnes Ole-Bjørn OB Evans Jonathan R JR Breen David P DP Estrada Karol K Wegel Claire E CE Danjou Fabrice F Simon David K DK Andreassen Ole O Ravina Bernard B Toft Mathias M Heutink Peter P Bloem Bastiaan R BR Weintraub Daniel D Barker Roger A RA Williams-Gray Caroline H CH van de Warrenburg Bart P BP Van Hilten Jacobus J JJ Scherzer Clemens R CR Singleton Andrew B AB Nalls Mike A MA
Movement disorders : official journal of the Movement Disorder Society 20190910 12
<h4>Background</h4>Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity and progression of Parkinson's disease, however, has not been well studied.<h4>Objectives</h4>To test the association between genetic variants and the clinical features of Parkinson's disease on a genomewide scale.<h4>Methods</h4>We accumulated individual data from 12 l ...[more]