Dataset Information

Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.

ABSTRACT:

Objective

The purpose of this study was to investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, ?-amyloid42 , ?-synuclein, neurofilament light, and YKL-40 change over time and if changes correlate with motor progression and/or cognitive decline in patients with PD and controls.

Methods

We included 63 patients with PD (nondemented) and 21 neurologically healthy controls from the prospective and longitudinal Swedish BioFINDER study, all of whom had clinical assessments and lumbar punctures at baseline and after 2 years.

Results

CSF tau levels correlated strongly with ?-synuclein. The levels of CSF ?-synuclein, tau, phosphorylated tau, neurofilament light, and YKL-40, but not ?-amyloid42 , increased in CSF over 2 years in PD. No changes were seen in the control group. Studying patients with a short disease duration (???5 years) and patients with a long disease duration (?>?5 years) separately, ?-synuclein and tau only increased in the PD group with long disease duration. In the PD group, an increase in phosphorylated tau over 2 years correlated with faster motor progression and faster cognitive decline. An increase in YKL-40 over 2 years correlated with faster cognitive decline.

Conclusion

CSF biomarkers reflecting Lewy body pathology and neurodegeneration (?-synuclein), neuronal degeneration (tau, phosphorylated tau, and neurofilament light), and inflammation (YKL-40) increase significantly over 2 years in PD. CSF levels of ?-synuclein and tau correlate and remain stable in the early symptomatic phase of PD but increase in the later phase. We hypothesize that CSF ?-synuclein levels might increase as a result of more intense neurodegeneration in PD with long disease duration. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

SUBMITTER: Hall S

PROVIDER: S-EPMC5067556 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.

Hall Sara S Surova Yulia Y Öhrfelt Annika A Blennow Kaj K Zetterberg Henrik H Hansson Oskar O

Movement disorders : official journal of the Movement Disorder Society 20160216 6

<h4>Objective</h4>The purpose of this study was to investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, β-amyloid42 , α-synuclein, neurofilament light, and YKL-40 change over time and if changes correlate with motor progression and/or cognitive decline in patients with PD and controls.<h4>Methods</h4>We included 63 patients with PD (nondemented) and 21 neurologically healthy controls from the prospective and longitudinal Swedish BioFINDER study, all of whom had clinic ...[more]

PMID: 26878815

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Dataset Information

Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.

Objective

Methods

Results

Conclusion

Publications

Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.

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