Ontology highlight
ABSTRACT:
SUBMITTER: Shu Y
PROVIDER: S-EPMC7019131 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
International journal of biological sciences 20200114 5
Acetaminophen (APAP) refers to a medication used to manage pain and fever symptoms, but it always causes liver injury when overdosed. Zhishi, dried young fruit of <i>Citrus aurantium L.</i>, is a famous <i>Citrus</i> herbal medicine in Asian countries which is rich in dietary phenolic substances. In this study, the mechanism of Zhishi protected against APAP-induced liver injury was studied more deeply by metabolomic strategy and pharmacological study. The metabolomics results demonstrated that Z ...[more]