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Correlation Between the APOB rs1042034 SNP and Blood Lipid Characteristics of 2 Ethnic Groups in China.


ABSTRACT: The apolipoprotein (Apo) B gene (APOB) is a susceptible gene for dyslipidemia. The purpose of this investigation was to explore the relationship between the APOB rs1042034 single-nucleotide polymorphism (SNP) and serum lipid levels in the Maonan and Han populations. A total of 598 Maonan participants and 609 Han participants were genotyped by polymerase chain reaction and restriction fragment length polymorphism, and the genotypes were also verified by sequencing. There were no differences in genotype and allele frequencies between the 2 ethnic groups or between males and females. The levels of triglyceride (TG) in Maonans were higher and high-density lipoprotein cholesterol was lower in the A allele carriers than the A allele noncarriers; the A allele carriers in Hans had higher TG levels and lower ApoA1/ApoB ratio than the A allele noncarriers (P < .05 for all). Subgroup analysis showed that the A allele carriers in Maonan females had higher TG levels and the A allele carriers in Han females had higher TG levels and lower ApoA1/ApoB ratio than the A allele noncarriers (P < .05 for all). In our study populations, there may be ethnicity- and/or sex-specific associations between the APOB rs1042034 SNP and serum lipid levels.

SUBMITTER: Zhang FH 

PROVIDER: S-EPMC7019501 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature

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Correlation Between the <i>APOB</i> rs1042034 SNP and Blood Lipid Characteristics of 2 Ethnic Groups in China.

Zhang Fen-Han FH   Yin Rui-Xing RX   Yao Li-Mei LM   Yan Rong-Qin RQ   Lu Li L   Su Yuan Y  

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20190101


The apolipoprotein (Apo) B gene (<i>APOB</i>) is a susceptible gene for dyslipidemia. The purpose of this investigation was to explore the relationship between the <i>APOB</i> rs1042034 single-nucleotide polymorphism (SNP) and serum lipid levels in the Maonan and Han populations. A total of 598 Maonan participants and 609 Han participants were genotyped by polymerase chain reaction and restriction fragment length polymorphism, and the genotypes were also verified by sequencing. There were no dif  ...[more]

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