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Back to The Fusion: Mitofusin-2 in Alzheimer's Disease.

ABSTRACT: Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer's disease (AD). Preservation of mitochondrial dynamics is fundamental for regulating the organelle's functions. Several proteins participate in the regulation of mitochondrial morphology and networks, and among these, Mitofusin 2 (Mfn2) has been extensively studied. This review focuses on the role of Mfn2 in mitochondrial dynamics and in the crosstalk between mitochondria and the endoplasmic reticulum, in particular in AD. Understanding how this protein may be related to AD pathogenesis will provide essential information for the development of therapies for diseases linked to disturbed mitochondrial dynamics, as in AD.

SUBMITTER: Sita G

PROVIDER: S-EPMC7019958 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Back to The Fusion: Mitofusin-2 in Alzheimer's Disease.

Sita Giulia G Hrelia Patrizia P Graziosi Agnese A Morroni Fabiana F

Journal of clinical medicine 20200102 1

Mitochondria are dynamic organelles that undergo constant fission and fusion. Mitochondria dysfunction underlies several human disorders, including Alzheimer's disease (AD). Preservation of mitochondrial dynamics is fundamental for regulating the organelle's functions. Several proteins participate in the regulation of mitochondrial morphology and networks, and among these, Mitofusin 2 (Mfn2) has been extensively studied. This review focuses on the role of Mfn2 in mitochondrial dynamics and in th ...[more]

PMID: 31906578

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