The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents.

ABSTRACT: BACKGROUND:Naphthoquine (NQ) is a suitable partner anti-malarial for the artemisinin-based combination therapy (ACT), which is recommended to be taken orally as a single-dose regimen. The metabolism of NQ was mainly mediated by CYP2D6, which is well-known to show gender-specific differences in its expression. In spite of its clinical use, there is limited information on the pharmacokinetics of NQ, and no data are available for females. In this study, the effect of gender on the pharmacokinetics and antiplasmodial efficacy of NQ in rodents was evaluated. The underlying factors leading to the potential gender difference, i.e., plasma protein binding and metabolic clearance, were also evaluated. METHODS:The pharmacokinetic profiles of NQ were investigated in healthy male or female rats after

SUBMITTER: Xie Y 

PROVIDER: S-EPMC7020547 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature