Dataset Information

Development of Phantom Material that Resembles Compression Properties of Human Brain Tissue for Training Models.

ABSTRACT: There is a need to quantify and reproduce the mechanical behavior of brain tissue for a variety of applications from designing proper training models for surgeons to enabling research on the effectiveness of personal protective gear, such as football helmets. The mechanical response of several candidate phantom materials, including hydrogels and emulsions, was characterized and compared to porcine brain tissue under similar strains and strain rates. Some candidate materials were selected since their compositions were similar to brain tissue, such as emulsions that mimic the high content of lipids. Others, like silicone, were included since these are currently used as phantom materials. The mechanical response of the emulsion was closer to that of the native porcine brain tissue than the other candidates. The emulsions, created by addition of oil to a hydrogel, were able to withstand compressive strain greater than 40%. The addition of lipids in the emulsions also prevented the syneresis typically seen with hydrogel materials. This allowed the emulsion material to undergo freeze-thaw cycles with no significant change in their mechanical properties.

SUBMITTER: Navarro-Lozoya M

PROVIDER: S-EPMC7021247 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Development of Phantom Material that Resembles Compression Properties of Human Brain Tissue for Training Models.

Navarro-Lozoya Miriam M Kennedy Marian S MS Dean Delphine D Rodriguez-Devora Jorge I JI

Materialia 20190816

There is a need to quantify and reproduce the mechanical behavior of brain tissue for a variety of applications from designing proper training models for surgeons to enabling research on the effectiveness of personal protective gear, such as football helmets. The mechanical response of several candidate phantom materials, including hydrogels and emulsions, was characterized and compared to porcine brain tissue under similar strains and strain rates. Some candidate materials were selected since t ...[more]

PMID: 32064462

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Project description:In vivo and ex vivo sensors have the potential to aid tracking and anti-poaching endeavours and provide new insights into rhinoceros physiology and environment. However, the propagation of electromagnetic signals in rhinoceros tissue is currently not known. We present simulation and agar models of the rhinoceros that allow the investigation of electromagnetic propagation by in vivo and ex vivo devices without the need for surgery. Since the dielectric properties of rhinoceros tissue have not been documented, the conductivity and permittivity of the skin, fat, muscle, blood and other organs are first approximated by means of a meta-analysis that includes animals with similar physical properties. Subsequently, we develop anatomical models that include dermal layers, internal organs and a skeleton. We also develop a flank model that serves as an approximation of the anatomical model in certain situations. These models are used to determine the viability of communication between an in vivo device and an ex vivo device attached to the hind leg of the animal. Two types of antenna (microstrip-fed planar elliptical monopole antenna and printed inverted-F antenna) and three feasible implant locations (back, neck and chest) are considered. In addition to the computer models, phantom recipes using salt, sugar and agar are developed to match the dielectric properties of each tissue type at the industrial, scientific and medical (ISM) frequencies of 403MHz, 910MHz and 2.4GHz. The average error between the measured and theoretically predicted dielectric values was 6.22% over all recipes and 4.49% for the 2.4 GHz recipe specifically. When considering the predicted efficiency of the transmitting and receiving antennas, an agreement of 67.38% was demonstrated between the computer simulations and laboratory measurements using the agar rhinoceros flank models. Computer simulations using the anatomical model of the rhinoceros indicate that the chest is the optimal implant location and that best signal propagation is achieved using the planar inverted-F antenna (PIFA). Using this configuration, the simulations indicate that communication between the implant and an ex vivo device attached to the hind leg is challenging but possible. Furthermore, we find that the inclusion of factors such as the density and temperature of the phantom materials were found to be critical to the achievement of good agreement between practice and simulation.

Dataset Information

Development of Phantom Material that Resembles Compression Properties of Human Brain Tissue for Training Models.

Publications

Development of Phantom Material that Resembles Compression Properties of Human Brain Tissue for Training Models.

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