Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida K
PROVIDER: S-EPMC7021511 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yoshida Kenichi K Gowers Kate H C KHC Lee-Six Henry H Chandrasekharan Deepak P DP Coorens Tim T Maughan Elizabeth F EF Beal Kathryn K Menzies Andrew A Millar Fraser R FR Anderson Elizabeth E Clarke Sarah E SE Pennycuick Adam A Thakrar Ricky M RM Butler Colin R CR Kakiuchi Nobuyuki N Hirano Tomonori T Hynds Robert E RE Stratton Michael R MR Martincorena Iñigo I Janes Sam M SM Campbell Peter J PJ
Nature 20200129 7794
Tobacco smoking causes lung cancer<sup>1-3</sup>, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA<sup>4,5</sup>. The profound effects of tobacco on the genome of lung cancer cells are well-documented<sup>6-10</sup>, but equivalent data for normal bronchial cells are lacking. Here we sequenced whole genomes of 632 colonies derived from single bronchial epithelial cells across 16 subjects. Tobacco smoking was the major influence on mutati ...[more]