Ontology highlight
ABSTRACT:
SUBMITTER: Nicholson AM
PROVIDER: S-EPMC5989058 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cell stem cell 20180517 6
We investigated the means and timing by which mutations become fixed in the human colonic epithelium by visualizing somatic clones and mathematical inference. Fixation requires two sequential steps. First, one of approximately seven active stem cells residing within each colonic crypt has to be mutated. Second, the mutated stem cell has to replace neighbors to populate the entire crypt in a process that takes several years. Subsequent clonal expansion due to crypt fission is infrequent for neutr ...[more]